Naltrexone – Benefits, Side Effects, And Precautions

Naltrexone For Weight Loss - Benefits, Side Effects, And Precautions

We discuss Naltrexone For Weight Loss, its benefits, side effects, and precautions. According to the World Health Organization (WHO), being overweight or obese refers to having excessive levels of body fat, which puts a person very vulnerable to a variety of health problems.

Advantages And Disadvantages Of Naltrexone

Even though not everyone who wants to lose weight is obese or overweight, many people have a hard time shedding the few pounds that they have gained over the course of their lives.

It is hard to lose weight by only following some measures such as exercise, walks, and dieting. 

Advantages And Disadvantages Of Naltrexone

Having a healthy and balanced lifestyle is the most reliable method for losing weight safely.

We can thank the research that led to the discovery of LDN, which may help you lose weight and maintain a healthy lifestyle.

In 1984, the Food and Drug Administration (FDA) granted approval for the use of naltrexone as a treatment for opioid addiction. The usage of naltrexone is widespread and has a lot of research behind it.

For example, the use of Naltrexone to aid in weight reduction has shown some promising outcomes, however, the specifics of the weight loss remain unknown.

It is recommended widely to lose weight easily. There are some precautionary measures that should be followed strictly too. 

Helpful In Weight Reduction

Several studies have shown the effects of naltrexone on weight reduction. These have produced major promising findings. The medication lessens the hunger that patients experience, which in turn facilitates their weight loss.

According to the findings of several studies, it may also be used with other drugs to provide a more potent impact.

It has been established that individuals may be successfully treated for obesity when they take the medication in conjunction with bupropion.

The appetite suppressant bupropion helps people take off excess weight by reducing their overall calorie intake. However, in addition to taking the medication, the patient will need to make adjustments to aspects of their lifestyle, including their food.


  • It would suggest that LDN aids in weight reduction via a variety of different pathways. Studies have shown that low-dose naltrexone (LDN) may help you feel fuller for longer by making food seem less appealing. 
  • As a direct consequence of this, you will find that your desire to eat will gradually diminish. Additionally, there is some speculation that LDN can help boost levels of growth hormone in the body.
  •  The production of lean muscle and an increased rate of fat burning are two of the ways that growth hormones may assist with weight reduction. Insulin resistance is another problem that has to be addressed. 
  • It plays a role in the development of obesity and weight gain, in addition to a number of other diseases such as diabetes, heart attacks, and strokes. 
  • Because LDN can lower insulin resistance, it not only has the potential to assist with weight reduction, but it may also be able to prevent or treat other ailments!

Typical Manifestations Of Naltrexone’s Adverse Effects

The use of naltrexone, like the use of any other medicine, is linked with several common adverse effects that are not dangerous.

The majority of the adverse effects that might occur from using naltrexone are moderate and pass on their own.

You should seek immediate medical attention if you have any of the following symptoms of an allergic response: fever, enlarged glands, mouth sores, muscle pain; hives, rashes, or itching; chest discomfort; difficulty breathing; swelling of the face, lips, tongue, or neck.

If you have shallow breathing that is interspersed with extended pauses, extreme sleepiness, or you are difficult to wake up, the person who is caring for you should seek immediate medical treatment for you.

Notify your healthcare professional as soon as you experience any of the following unwanted effects that become bothersome. 

Liver damage

The use of naltrexone has been linked to elevations in serum liver enzymes in as many as fifty percent of patients. These elevations are typically mild and resolve on their own over time.

It is necessary to discontinue treatment with naltrexone if the elevations in question reach more than three times the upper limit of what is considered normal in approximately one percent of those who are taking the medication.


The usage of naltrexone, like the use of many other drugs, is often accompanied by the unpleasant side effect of nausea. Nausea is a common side effect of using naltrexone, however, it is often moderate and short-lived. The presence of severe nausea is often a warning sign that something else is amiss.


It is fairly normal for people to experience feelings of fatigue, tiredness, and sleepiness after taking drugs that have an impact on the opiate receptors.

When administered at larger dosages, naltrexone is much more likely to have this effect. Contrary to common belief, low-dose naltrexone, often known as LDN, has been used successfully off-label to help treat tiredness.

A Decreased Desire To Eat

On its own, naltrexone is known to have an appetite-suppressing effect and to lessen the allure of food.

The use of naltrexone might lead to weight loss on its own; nevertheless, a decrease in appetite is typically considered to be a desirable side effect for persons who are worried about rising appetite or weight gain as a result of changes in lifestyle or modifications in medication.


There are several precautionary measures that need to be kept in mind while consuming it. Before beginning to use this medication

  • If you are pregnant, you should not take the drugs bupropion and naltrexone. Even if you are at a healthy weight, going on a diet during pregnancy might put the unborn child in danger. If you get pregnant, you should contact your physician as soon as possible.
  • Do not use this medication if you have an allergy to bupropion or naltrexone, or if you have any of the following conditions:
  • Untreated or uncontrolled high blood pressure;
  • a problem with their appetites, such as anorexia or bulimia;
  • if you have an opioid use disorder or are going through withdrawal, or if you are on methadone or buprenorphine:
  • if you are taking Wellbutrin, Aplenzin, Budeprion, Forfivo, Zyban, or any of the other versions of bupropion; or if you are taking Zyban.
  • The withdrawal symptoms may occur if you suddenly stopped the consumption of alcohol, a sedative such as Valium, Fiorinal, Xanax, Klonopin, or medicine for seizures.

The Concluding Notes

The final verdict on Naltrexone for weight loss is as follows. Naltrexone (LDN) may help you feel fuller for longer by making food seem less appealing. The appetite suppressant bupropion helps people take off excess weight by reducing their overall calorie intake.

The drug naltrexone has been linked with several common adverse effects that are not dangerous. Nausea is a common side effect, however, it is often moderate and short-lived.

It is believed to be an effective drug in weight loss. It can help obese people to shed extra pounds off their bodies.

There may be some side effects experienced by the users. Notify your healthcare professional if you experience any of the following unwanted side effects. The use of naltrexone might lead to weight loss on

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